Weight gain following subthalamic nucleus deep brain stimulation: a PET study.
Identifieur interne : 000811 ( Main/Exploration ); précédent : 000810; suivant : 000812Weight gain following subthalamic nucleus deep brain stimulation: a PET study.
Auteurs : Paul Sauleau [France] ; Florence Le Jeune ; Sophie Drapier ; Jean-François Houvenaghel ; Thibaut Dondaine ; Claire Haegelen ; Florent Lalys ; Gabriel Robert ; Dominique Drapier ; Marc VérinSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Glucose.
- metabolism : Cerebral Cortex, Parkinson Disease.
- methods : Deep Brain Stimulation, Positron-Emission Tomography.
- physiology : Subthalamic Nucleus, Weight Gain.
- therapy : Parkinson Disease.
- Body Mass Index, Humans.
Abstract
Several hypotheses have been put forward to explain weight gain after deep brain stimulation (DBS), but none provides a fully satisfactory account of this adverse effect. We analyzed the correlation between changes in brain metabolism (using positron emission tomography [PET] imaging) and weight gain after bilateral subthalamic nucleus DBS in patients with Parkinson's disease. Body mass index was calculated and brain activity prospectively measured using 2-deoxy-2[18F]fluoro-D-glucose 3 months before and 4 months after the start of subthalamic nucleus deep brain stimulation in 23 patients with Parkinson's disease. Motor complications (United Parkinson's Disease Rating Scale [UPDRS]-IV scores) and dopaminergic medication were included in the analysis to control for their possible influence on brain metabolism. Mean ± standard deviation (SD) body mass index increased significantly by 0.8 ± 1.5 kg/m(2) (P = 0.03). Correlations were found between weight gain and changes in brain metabolism in limbic and associative areas, including the orbitofrontal cortex (Brodmann areas [BAs] 10 and 11), lateral and medial parts of the temporal lobe (BAs 20, 21, 22,39 and 42), anterior cingulate cortex (BA 32), and retrosplenial cortex (BA 30). However, we found no correlation between weight gain and metabolic changes in sensorimotor areas. These findings suggest that changes in associative and limbic processes contribute to weight gain after subthalamic nucleus DBS in Parkinson's disease.
Url:
DOI: 10.1002/mds.26063
PubMed: 25382049
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000462
- to stream PubMed, to step Curation: 000453
- to stream PubMed, to step Checkpoint: 000453
- to stream Ncbi, to step Merge: 001554
- to stream Ncbi, to step Curation: 001554
- to stream Ncbi, to step Checkpoint: 001554
- to stream Hal, to step Corpus: 000B94
- to stream Hal, to step Curation: 000B94
- to stream Hal, to step Checkpoint: 000222
- to stream Main, to step Merge: 000813
- to stream Main, to step Curation: 000811
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Weight gain following subthalamic nucleus deep brain stimulation: a PET study.</title><author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name><affiliation wicri:level="3"><nlm:affiliation>"Behavior and Basal Ganglia" research unit (EA 4712), University of Rennes 1, Rennes, France; Rennes University Hospital, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>"Behavior and Basal Ganglia" research unit (EA 4712), University of Rennes 1, Rennes, France; Rennes University Hospital, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Le Jeune, Florence" sort="Le Jeune, Florence" uniqKey="Le Jeune F" first="Florence" last="Le Jeune">Florence Le Jeune</name></author><author><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name></author><author><name sortKey="Houvenaghel, Jean Francois" sort="Houvenaghel, Jean Francois" uniqKey="Houvenaghel J" first="Jean-François" last="Houvenaghel">Jean-François Houvenaghel</name></author><author><name sortKey="Dondaine, Thibaut" sort="Dondaine, Thibaut" uniqKey="Dondaine T" first="Thibaut" last="Dondaine">Thibaut Dondaine</name></author><author><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name></author><author><name sortKey="Lalys, Florent" sort="Lalys, Florent" uniqKey="Lalys F" first="Florent" last="Lalys">Florent Lalys</name></author><author><name sortKey="Robert, Gabriel" sort="Robert, Gabriel" uniqKey="Robert G" first="Gabriel" last="Robert">Gabriel Robert</name></author><author><name sortKey="Drapier, Dominique" sort="Drapier, Dominique" uniqKey="Drapier D" first="Dominique" last="Drapier">Dominique Drapier</name></author><author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25382049</idno><idno type="pmid">25382049</idno><idno type="doi">10.1002/mds.26063</idno><idno type="wicri:Area/PubMed/Corpus">000462</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000462</idno><idno type="wicri:Area/PubMed/Curation">000453</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000453</idno><idno type="wicri:Area/PubMed/Checkpoint">000453</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000453</idno><idno type="wicri:Area/Ncbi/Merge">001554</idno><idno type="wicri:Area/Ncbi/Curation">001554</idno><idno type="wicri:Area/Ncbi/Checkpoint">001554</idno><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-01133822</idno><idno type="url">https://hal-univ-rennes1.archives-ouvertes.fr/hal-01133822</idno><idno type="wicri:Area/Hal/Corpus">000B94</idno><idno type="wicri:Area/Hal/Curation">000B94</idno><idno type="wicri:Area/Hal/Checkpoint">000222</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000222</idno><idno type="wicri:doubleKey">0885-3185:2014:Sauleau P:weight:gain:following</idno><idno type="wicri:Area/Main/Merge">000813</idno><idno type="wicri:Area/Main/Curation">000811</idno><idno type="wicri:Area/Main/Exploration">000811</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Weight gain following subthalamic nucleus deep brain stimulation: a PET study.</title><author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name><affiliation wicri:level="3"><nlm:affiliation>"Behavior and Basal Ganglia" research unit (EA 4712), University of Rennes 1, Rennes, France; Rennes University Hospital, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>"Behavior and Basal Ganglia" research unit (EA 4712), University of Rennes 1, Rennes, France; Rennes University Hospital, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Le Jeune, Florence" sort="Le Jeune, Florence" uniqKey="Le Jeune F" first="Florence" last="Le Jeune">Florence Le Jeune</name></author><author><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name></author><author><name sortKey="Houvenaghel, Jean Francois" sort="Houvenaghel, Jean Francois" uniqKey="Houvenaghel J" first="Jean-François" last="Houvenaghel">Jean-François Houvenaghel</name></author><author><name sortKey="Dondaine, Thibaut" sort="Dondaine, Thibaut" uniqKey="Dondaine T" first="Thibaut" last="Dondaine">Thibaut Dondaine</name></author><author><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name></author><author><name sortKey="Lalys, Florent" sort="Lalys, Florent" uniqKey="Lalys F" first="Florent" last="Lalys">Florent Lalys</name></author><author><name sortKey="Robert, Gabriel" sort="Robert, Gabriel" uniqKey="Robert G" first="Gabriel" last="Robert">Gabriel Robert</name></author><author><name sortKey="Drapier, Dominique" sort="Drapier, Dominique" uniqKey="Drapier D" first="Dominique" last="Drapier">Dominique Drapier</name></author><author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Body Mass Index</term><term>Cerebral Cortex (metabolism)</term><term>Deep Brain Stimulation (methods)</term><term>Glucose (metabolism)</term><term>Humans</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (therapy)</term><term>Positron-Emission Tomography (methods)</term><term>Subthalamic Nucleus (physiology)</term><term>Weight Gain (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glucose</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cerebral Cortex</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term><term>Positron-Emission Tomography</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term><term>Weight Gain</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Body Mass Index</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several hypotheses have been put forward to explain weight gain after deep brain stimulation (DBS), but none provides a fully satisfactory account of this adverse effect. We analyzed the correlation between changes in brain metabolism (using positron emission tomography [PET] imaging) and weight gain after bilateral subthalamic nucleus DBS in patients with Parkinson's disease. Body mass index was calculated and brain activity prospectively measured using 2-deoxy-2[18F]fluoro-D-glucose 3 months before and 4 months after the start of subthalamic nucleus deep brain stimulation in 23 patients with Parkinson's disease. Motor complications (United Parkinson's Disease Rating Scale [UPDRS]-IV scores) and dopaminergic medication were included in the analysis to control for their possible influence on brain metabolism. Mean ± standard deviation (SD) body mass index increased significantly by 0.8 ± 1.5 kg/m(2) (P = 0.03). Correlations were found between weight gain and changes in brain metabolism in limbic and associative areas, including the orbitofrontal cortex (Brodmann areas [BAs] 10 and 11), lateral and medial parts of the temporal lobe (BAs 20, 21, 22,39 and 42), anterior cingulate cortex (BA 32), and retrosplenial cortex (BA 30). However, we found no correlation between weight gain and metabolic changes in sensorimotor areas. These findings suggest that changes in associative and limbic processes contribute to weight gain after subthalamic nucleus DBS in Parkinson's disease.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Région Bretagne</li></region><settlement><li>Rennes</li></settlement></list><tree><noCountry><name sortKey="Dondaine, Thibaut" sort="Dondaine, Thibaut" uniqKey="Dondaine T" first="Thibaut" last="Dondaine">Thibaut Dondaine</name><name sortKey="Drapier, Dominique" sort="Drapier, Dominique" uniqKey="Drapier D" first="Dominique" last="Drapier">Dominique Drapier</name><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name><name sortKey="Houvenaghel, Jean Francois" sort="Houvenaghel, Jean Francois" uniqKey="Houvenaghel J" first="Jean-François" last="Houvenaghel">Jean-François Houvenaghel</name><name sortKey="Lalys, Florent" sort="Lalys, Florent" uniqKey="Lalys F" first="Florent" last="Lalys">Florent Lalys</name><name sortKey="Le Jeune, Florence" sort="Le Jeune, Florence" uniqKey="Le Jeune F" first="Florence" last="Le Jeune">Florence Le Jeune</name><name sortKey="Robert, Gabriel" sort="Robert, Gabriel" uniqKey="Robert G" first="Gabriel" last="Robert">Gabriel Robert</name><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name></noCountry><country name="France"><region name="Région Bretagne"><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000811 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000811 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:25382049
|texte= Weight gain following subthalamic nucleus deep brain stimulation: a PET study.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25382049" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |